PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) ON HUMAN DISEASED THYROID CELLS
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چکیده
منابع مشابه
Proliferating cell nuclear antigen (PCNA): a dancer with many partners.
Proliferating cell nuclear antigen (PCNA) was originally characterised as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the eukaryotic chromosomal DNA replisome. Subsequent studies, however, have revealed its striking ability to interact with multiple partners, which are involved in several metabolic pathways, including Okazaki fragment processing, DNA rep...
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Proliferating cell nuclear antigen (PCNA) is an auxiliary protein of DNA • @polymerase-• Ý • @ that • @is • @ synthesized • @ during • @ the • @ late • @G1 • @ phase through the S phase of cell proliferation. The expression of PCNA correlates strongly with cell proliferation. In the present study, employing NC-012, which is an anti-human PCNA monoclonal antibody, we performed immunohistochemica...
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Immunohistochemistry of the S phase related proliferating cell nuclear antigen (PCNA) was studied as an alternative to ex-vivo bromodeoxyuridine (BrdU) immunohistochemistry for assessment of human colonic cell proliferation. From 16 subjects without colonic disease biopsy specimens were collected from five different sites along the colorectum and processed for BrdU and PCNA immunohistochemistry...
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PCNA and esophagin have been implicated in the multistep process of carcinogenesis, but simultaneous characterization of these proteins in the early stages of esophageal neoplastic progression has yet to be undertaken. In morphologically normal esophageal epithelium, esophagin stains the granular layer cells, principally in their cell membrane portions. PCNA, in contrast, stains the nuclei of c...
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AIMS To correlate the expression of proliferating cell nuclear antigen (PCNA) with various clinicopathological features of papillary thyroid carcinoma. METHODS Sections from 131 formalin fixed, paraffin wax embedded papillary thyroid carcinomas were stained with a monoclonal antibody (PC10) directed against PCNA using the avidin-biotin immunoperoxidase (ABC) method. PCNA immunoreactivity was ...
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ژورنال
عنوان ژورنال: Nippon Jibiinkoka Gakkai Kaiho
سال: 1993
ISSN: 0030-6622,1883-0854
DOI: 10.3950/jibiinkoka.96.651